Isla Fisher opens up on balancing motherhood with her skyrocketing career and admits “you can’t have it all and you shouldn’t want to.”

The 37-year-old actress, who is married to Sacha Baron Cohen, says that nothing is more important than being a mother in an interview with Gotham magazine.

“I took three years off. It’s not like you’re taking a break and looking on IMDbPro to see your StarMeter falling. You’re doing the most important, incredible thing,” said the London-based Aussie actress, soon to be seen in The Great Gatsby.

The couple, who married in 2010, have two daughters: Olive, five, and Elula, two.

“When you come back in, the perspective has changed. I truly believe you can’t have it all and you shouldn’t want to,” she added.

But don’t expect to see her and her comedian husband on screen together anytime soon. “Personally, I think we collaborate on enough behind closed doors…We’re working on some really important collaborations, and I think that’s more important.”

And she took the time to gush about Cohen, adding “Obviously, I’m a big fan of his. My favorite movie will always be Bruno, and my favorite line will always be when he looks up at the sky and goes, ”So many stars in the sky. Makes you think of all the hot guys in the world.” So freaking random and funny.”

The Wedding Crashers and Bacheorette star describes filming The Great Gatsby in Australia as ” thrilling and terrifying. Given the caliber of the director and cast on Gatsby, I definitely felt out of my comfort zone. I did feel like I was going to be called out and sent home at some point — you always feel very insecure, at least I do.”

Fisher, who plays the role of Myrtle Wilson, said ‘the set was like a playground of rich costumes (his wife Catherine Martin does them) and color and music and laughter…Everybody cares on a Baz Luhrmann film set because everyone is so effing grateful to be there.”

What do you think? Can women have it all?